1'-aryl-4'-hydroxy-3'-cinnamoyl-2H, 4H-spiro furo 3,2-c chromene-3,2'-pyrrolyl -2,4,5 '(1'N) -trione, exerts its analgesic activity, and methods of making

摘要

1. 1'-aryl-4'-hydroxy-3'-cinnamoyl-2H, 4H-spiro [furo [3,2-c] chromene-3,2'-pyrrole] -2,4,5 '(1' H) -trione formulyIgde III, Ar = Ph (a) CHME-4 (b), sleep-4 (a) .2. 1'-aryl-4'-hydroxy-3'-cinnamoyl-2H, 4H-spiro [furo [3,2-c] chromene-3,2'-pyrrole] -2,4,5 '(1'N) -trione the formula III, Ar = Ph (a), the sleep-4 (c), analgesic having aktivnostyu.3. A process for preparing aryl-1'-4'-hydroxy-3'-cinnamoyl-2H, 4H-spiro [furo [3,2-c] chromene-3,2'-pyrrole] -2,4,5 '(1H) -trione, characterized in that the methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate (Ia-c) was reacted with 4-hydroxy-2H-chromen -2-oxazolidinone (II) in an inert aprotic solvent - toluene, at a temperature of 108-110 ° C for 2-3 chasovgde III, Ar = Ph (a), CHMe-4 (b), CHOMe-4 (c) .4. . A method according to claim 3, characterized in that the process is carried out at a temperature of 108-110 ° C - the boiling point of toluene.