FUNCTIONAL PLG COPOLYMERS, THEIR NANOPARTICLES, THEIR PRODUCTION AND APPLICATION FOR ADDRESSED DELIVERY OF THE MEDICINE AND OBTAINING THE IMAGE

摘要

1. The compound of formula (A), where: PLA is a polylactide residue; PEG is a polyethylene glycolide residue; linker PEG 'is a polyethylene glycolide residue; The ligand is the remainder of the functional ligand. 2. The compound of formula (A) according to claim 1, where PEG 'has the formula, where: n' is the number of units and is equal to from 1 to 10, (1) is the addition of a bond to the - (CH) -triazole group; (2) is the addition bonds to the ligand. 3. The compound of formula (A) according to claim 1 or 2, wherein the PL has the formula: wherein: (3) is a bond attachment to a PEG group; and m is the number of units and is equal to from 1 to 500.4. The compound of formula (A) according to claim 1 or 2, where the PEG has the formula: where: (4) is the attachment of a bond to -PL; (5) is the attachment of a bond to a nitrogen atom and n is the number of units and is equal to from 1 and 300.5. The compound of formula (A) according to claim 1 or 2, wherein the ligand is selected from the residues of the guidance device, diagnostic agents, imaging agents, stimulus-sensitive agents, coupling agents, cell penetration enhancing agents, antitoxic components and drugs. . The compound of formula (A) according to claim 5, wherein said pointing device is a ligand-recognizing membrane. The compound of formula (A) according to claim 1 or 2, wherein the ligand is selected from: ligands that recognize membranes selected from an estrogen receptor antagonist, an androgen receptor antagonist, folic acid, anisamide, an antibody capable of recognizing the corresponding surface antigen, an RGD sequence that binds with αβ integrins overly expressed on the angiogenic endothelium of the tumor, hyaluronic acid, transferrin, peptide-directed gene vectors, aptamers or tumor necrosis factor, diagnostic / receiving agents and