POROUS BODY, AND CARRIER FOR MONOLITH AFFINITY CHROMATOGRAPHY, MONOLITH RESIN BEAD AND MONOLITH REACTOR CARRIER USING THE SAME, AND METHOD FOR PRODUCING POROUS BODY

摘要

PROBLEM TO BE SOLVED: To provide a porous body which can purify an antibody and the like at high speed and low cost.SOLUTION: A porous body is formed of a polymer resin, which has continuous holes having a pore diameter of 1-100 μm, has a porosity of 50% or more, and has a functional group on the surface capable of bonding to a protein. The porous body having protein A bonded to the functional group as a ligand is excellent in water permeability and pressure resistance, and accordingly can adsorb a specific substance at a high flow rate.By using an ethylene-glycidyl methacrylate copolymer as a polymer substrate, an epoxy group as the functional group is easily introduced to the surface thereof, and accordingly the protein A can be easily bonded to the porous body as the ligand. A separation device in which a column is filled with the porous body as a carrier, the porous body having the ligand bonded, can purify an antibody such as IgG at high speed and low cost.SELECTED DRAWING: Figure 2