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Branched polyethylene glycol bound to diacylglycerol, their preparation and polyethylene glycol-modified liposome
Branched polyethylene glycol bound to diacylglycerol, their preparation and polyethylene glycol-modified liposome
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机译:与二酰基甘油结合的支链聚乙二醇,其制备方法和聚乙二醇修饰的脂质体
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摘要
PROBLEM TO BE SOLVED: To provide a polyethylene glycol derivative which includes two PEG chains, which is bound to a diacylglycerol, which has high purity, and which enhances the stability of liposomes.;SOLUTION: The branched polyethylene glycol bound to the diacylglycerol is represented by formula (1). (In formula (1), R1 is 1-7C hydrocarbon group, R2 is 9-21C alkyl or alkenyl, n is an average addition mole number of polyethylene glycol chains, 10≤n≤100, and X is a linker site between the branched polyethylene glycol and the diacylglycerol, and is represented by formula (2)). (In formula (2), Y is ether bond, ester bond, urethane bond, amide bond, or carbonate bond, and each of l and m is an integer of 0 to 6).;COPYRIGHT: (C)2013,JPO&INPIT
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