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GPC3-Targeting Drug Which Is Administered To Patient Responsive To GPC3-Targeting Drug Therapy

机译:对对GPC3靶向药物治疗有反应的患者使用的GPC3靶向药物

摘要

A method is provided for determining the efficacy of GPC3-targeting drug therapy for cancer in a patient before the start of GPC3-targeting drug therapy or for determining the continuation of GPC3-targeting drug therapy for a patient treated with GPC3-targeting therapy. The method includes determining the number of an immunocyte or an expression level of a molecule expressed on the immunocyte in a biological sample isolated from the patient before the start of GPC3-targeting drug therapy and/or the patient treated with the GPC3-targeting drug therapy, wherein when the number of the immunocyte or the expression level of the molecule expressed on the immunocyte is a predetermined value, the efficacy of the GPC3-targeting drug therapy is determined or the continuation of the GPC3-targeting drug therapy is determined. GPC3-targeting drugs and drug preparations for use according to the disclosed methods are also provided.
机译:提供了一种方法,该方法用于在开始靶向GPC3的药物治疗之前确定针对患者的GPC3靶向药物治疗的疗效,或者确定针对接受GPC3靶向治疗的患者继续进行靶向GPC3药物治疗的方法。该方法包括确定在开始靶向GPC3的药物治疗和/或接受靶向GPC3的药物治疗的患者开始之前从患者体内分离出的生物样品中免疫细胞的数目或免疫细胞上表达的分子的表达水平。 ,其中当免疫细胞的数目或在免疫细胞上表达的分子的表达水平是预定值时,确定靶向GPC3的药物治疗的效力或确定靶向GPC3的药物治疗的继续。还提供了根据公开的方法使用的靶向GPC3的药物和药物制剂。

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