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Fluoropolymer Emulsions with Branched Semifluorinated Block Copolymer or Phospholipid Surfactant for the Delivery of Hydrophobic Drugs
Fluoropolymer Emulsions with Branched Semifluorinated Block Copolymer or Phospholipid Surfactant for the Delivery of Hydrophobic Drugs
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机译:含支链半氟化嵌段共聚物或磷脂表面活性剂的含氟聚合物乳液,用于输送疏水性药物
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摘要
The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds, including an important class of hydrophobic anesthetics. Formulations and methods of the invention include semifluorinated block copolymers, and optionally phospholipid surfactants, capable of forming a stable nanoemulsion without the need of conventional lipid components that support bacterial and/or fungal growth (e.g., soybean oil and similar lipids). In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including inducing and maintaining anesthesia in patients. In certain embodiments, emulsion-based formulations are provided that are capable of supporting controlled release, for example, over a range of rates useful for clinical applications including rapid and sustained release.
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