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Target for Firmicutes and Related Bacteria: The PRP Protease
Target for Firmicutes and Related Bacteria: The PRP Protease
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机译:坚定和相关细菌的目标:PRP蛋白酶
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摘要
L27 in Staphylococcus aureus and other Firmicutes is encoded with an N-terminal extension that is not present in most Gram-negative organisms and is absent from mature ribosomes. We have identified a cysteine protease, conserved among bacteria containing the L27 N-terminal extension, which performs post-translational cleavage of L27. The provided methods have utility for the development of new therapeutic antibiotics that target this novel pathway in order to kill pathogenic Firmicutes and related bacteria.
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