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IN VITRO BIOSIMULATOR TO INDUCE PATTERN FORMATION IN NON-ADHERENT CELLS
IN VITRO BIOSIMULATOR TO INDUCE PATTERN FORMATION IN NON-ADHERENT CELLS
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机译:体外BIOSimulator诱导非粘附细胞中的细胞形成
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摘要
It is not understood what causes or influences pattern formation in cells during the development of an organism. When animal/human cells are cultured in a Petri dish the adherent cells attach to the bottom of the dish, whereas the non-adherent cells float in the growing medium. Currently there are no specialized dishes for culturing non-adherent cells. We now show that non-adherent cells could be induced to form distinct patterns when cultured in an etched plastic dish (Biosimulator). The non-adherent cells showed polarity when cultured in the etched plate. The polarity/pattern formation could be reversed with inhibitors specific for adhesion proteins. The phenomenon of pattern formation by non-adherent cells has wide applications in cell and developmental biology, diagnostics, microbiome research, biofluidics, drug discovery, industrial production of biological products, and also in biotechnology and bioengineering.
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