首页>
外国专利>
GENETICALLY MODIFIED COCCIDIAN PARASITES USEFUL AS VACCINES
GENETICALLY MODIFIED COCCIDIAN PARASITES USEFUL AS VACCINES
展开▼
机译:经遗传修饰的球虫寄生虫用作疫苗
展开▼
页面导航
摘要
著录项
相似文献
摘要
A genetically modified coccidian parasites wherein expression of phosphatidylthreonine synthase (PTS) is disrupted, a polynucleotide including a nucleotide sequence encoding a phosphatidylthreonine synthase (PTS) enzyme, which catalyzes the production of a lipid, phosphatidylthreonine (PtdThr). PtdThr is an exclusive, major and physiologically important lipid in selected coccidian parasites, which is required for a normal growth and virulence of coccidian parasites. Coccidian parasites, having the expression of PTS disrupted as described herein, are useful as vaccines. The phosphatidylthreonine synthase enzyme and the nucleotide encoding sequences thereof as well as the phosphatidylthreonine phospholipid can find use in diagnostic methods and diagnostic kits or in vaccine and drug development applications.
展开▼