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Monoclonal antibodies targeting EpCAM for detection of prostate cancer lymph node metastases
Monoclonal antibodies targeting EpCAM for detection of prostate cancer lymph node metastases
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机译:靶向EpCAM的单克隆抗体可检测前列腺癌淋巴结转移
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摘要
Embodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via surgical field near-infrared fluorescence (NIRF) imaging following (in the case of dual labeled agents) nuclear imaging for general localization. Currently, nodal staging of most cancers is performed following lymph node (LN) biopsy and dissection for subsequent pathological examination.
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