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Single nucleotide polymorphisms and community-associated methicillin-resistant Staphylococcus aureus

机译：单核苷酸多态性与社区相关性耐甲氧西林金黄色葡萄球菌

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摘要

The present invention is based on the discovery of polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present invention provides reagents used for detecting the SNPs as well as methods of identifying and using these variants to screen subjects for presence of CA-MRSA. The methods involve isolating a biological sample from a mammal (preferably a human) and testing for the presence of a SNP in the pbp3 gene which is associated with CA-MRSA.

机译：本发明是基于金黄色葡萄球菌中青霉素结合蛋白（pbp3）基因的多态性（SNP）的发现。 G88A和/或G2047A SNP的存在为耐甲氧西林的金黄色葡萄球菌（MRSA），特别是与社区相关的MRSA（CA-MRSA）的存在提供了准确，可靠的生物标记。本发明提供了用于检测SNP的试剂，以及鉴定和使用这些变体以筛选受试者是否存在CA-MRSA的方法。该方法包括从哺乳动物（优选人）分离生物样品，并测试与CA-MRSA相关的pbp3基因中是否存在SNP。 展开▼

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公开/公告号US9738938B2

专利类型

公开/公告日2017-08-22

原文格式PDF

申请/专利权人 SCOTT E. GYGAX;SEAN CHADWICK;ADITYA PRASAD;MARTIN E. ADELSON;ELI MORDECHAI;
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申请/专利号US201113068331

发明设计人 SCOTT E. GYGAX;ADITYA PRASAD;MARTIN E. ADELSON;ELI MORDECHAI;SEAN CHADWICK;
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申请日2011-05-09

分类号C12Q1/68;C07H21/04;

国家 US

入库时间 2022-08-21 13:45:46

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