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Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway

机译：抑制PI3K / AKT / mTOR信号通路的方法和药物组合物

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摘要

The present invention relates to a pharmaceutical composition of PRCP antagonist, PREP antagonist, or PRCP-PREP dual antagonist. The present invention also relates to a pharmaceutical composition jointly using PRCP antagonist and mTOR antagonist, or jointly using PREP antagonist and mTOR antagonist, or jointly using PRCP-PREP dual antagonist and mTOR antagonist. In addition, the present invention also relates to a method for utilizing the pharmaceutical compositions to treat and prevent cancers and diseases related to insulin receptor substrate protein and PI3K/AKT/mTOR signal pathway.

机译：本发明涉及PRCP拮抗剂，PREP拮抗剂或PRCP-PREP双重拮抗剂的药物组合物。本发明还涉及联合使用PRCP拮抗剂和mTOR拮抗剂，或者联合使用PREP拮抗剂和mTOR拮抗剂，或者联合使用PRCP-PREP双重拮抗剂和mTOR拮抗剂的药物组合物。另外，本发明还涉及利用所述药物组合物治疗和预防与胰岛素受体底物蛋白和PI3K / AKT / mTOR信号途径有关的癌症和疾病的方法。

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公开/公告号US9545396B2

专利类型
公开/公告日2017-01-17

原文格式PDF
申请/专利权人 TARGETED THERAPEUTICS LLC;
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申请/专利号US201314431441
发明设计人 LEI DUAN;VICTOR LEVENSON;GUOGUANG YING;
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申请日2013-09-29
分类号A01N43/36;A61K31/40;A61K31/436;A61K31/7105;A61K31/4025;A61K31/381;C12N15/113;A61K45/06;A61K31/4436;A61K31/4439;A61K31/7052;
国家 US
入库时间 2022-08-21 13:44:04

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