Intra-articularly supplementation method for treating joint diseases and injuries

摘要

A hydrogel bead for intra-articular supplement made by:providing a solution of alginate,providing a solution with chitosan having a Mw between lower than 60 kD,mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7% (w/v) of chitosan and between 1 and 1.4% alginate (w/v),introducing droplets of the mixed solution into a solution with Ca²⁺ or Sr²⁺ cations andisolating polymerised beads from the solution with cations.