The present Disclosure provides the use of variants of c type natriuretic peptide (CNP), and Pharmaceutical compositions and formulations comprising of Variant peptides for the treatment of CNP, Skeletal dysplasias, one or more symptoms of Skeletal dysplasias, such as The Growth of Long Bone or the growth SpeedAnd other Disorders that have a Skeletal dysplasia and / or component or Symptom associated with NPC.Claim 1: a formulation comprising: (a) a Variant Peptide selected from the group consisting of CNP in qehpnarkykgankkglskgcfglkldrigsnsglgc CNP (m32n) [37]; SEQ ID no. 1; mqehpnarkykgankkglskgcfglkldrigsmsglgc (MET - CNP - 37; pqehpnarkykgankkglskgcfglkldrigsmsglgc SEQ ID no. 2); (Pro CNP - 37; SEQ ID no. 3); gqehpnarkykgankkglskgcfglkldrigsnsglgc [Gly CNP - 37 (m32n); pgqehp SEQ ID no. 4];Narkykgankkglskgcfglkldrigsmsglgc (Pro Gly - CNP - SEQ ID no. 37; (5); mgqehpnarkykgankkglskgcfglkldrigsmsglgc met Gly CNP - 37; SEQ ID no. (6); and gqehpnarkykgankkglskgcfglkldrigsmsglgc Gly or NPC NPC - 37 - 38: SEQ ID no. 7); and (b) one or more selected from the group consisting of components an agent of T Amponamiento, a isotonicidad Agent, a Stabilizer and a antiadsorbente Agent.
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机译：本公开提供了c型利钠肽（CNP）变体和包含变体肽的药物组合物和制剂在治疗CNP，骨骼发育不良，一种或多种骨骼发育不良的症状例如长骨生长中的用途。权利要求1：一种制剂，其包含：（a）选自qehpnarkykgankkglskgcfglkldldsnsglgc CNP（m32n）中的CNP的变体肽[37];或具有与NPC有关的骨骼发育不良和/或组成部分或症状的生长速度和其他疾病。 ]; SEQ ID No. 1; mqehpnarkykgankkglskgcfglkldrigsmsglgc（MET-CNP-37; pqehpnarkykgankkglskgcfglkldrigsmsglgc SEQ ID no.2）; （Pro CNP-37; SEQ ID No.3）; gqehpnarkykgankkglskgcfglkldrigsnsglgc [Gly CNP-37（m32n）; pgqehp SEQ ID号4]; Narkykgankkglskgcfglkldrigsmsglgc（Pro Gly-CNP-SEQ ID no.37;（5）; mgqehpnarkykgankkglskgcfglkldrigsmsglgc符合Gly CNP-37; SEQ ID no。（6）;和gqehpnarkykgangkg NgS -SEQ ID no。（6） 7）; （b）一种或多种选自以下的组分：氨苯甲酰胺（T Amponamiento）剂，等渗剂，稳定剂和抗吸附剂。
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