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n- 4- (1h-pyrazolo 3,4-b pyrazin-6-yl) phenyl sulfonamides, process for their preparation, composition comprising it and its use as pharmaceuticals
n- 4- (1h-pyrazolo 3,4-b pyrazin-6-yl) phenyl sulfonamides, process for their preparation, composition comprising it and its use as pharmaceuticals
Patent Summary: "N- [4- (1h-pyrazolo [3,4-b] pyrazin-6-yl) -phenyl] sulfonamides and their use as pharmaceuticals". The present invention relates to n- [4- (1h-pyrazolo [3,4-b] pyrazin-6-yl) -phenyl] sulfonamides of the formula I, wherein ar, r1, r2 and n have the indicated meanings in the claims. The compounds of formula I are valuable pharmacologically active compounds that modulate protein kinase activity, specifically serum and glucocorticoid-regulated kinase (sgk) activity, in particular serum and glucocorticoid-regulated kinase isoform 1 (sgk-1, sgk1) , and is suitable for the treatment of diseases in which sgk activity is inappropriate, for example degenerative joint disorders or inflammatory processes such as osteoarthritis or rheumatism. The invention further relates to processes for the preparation of the compounds of formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
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