fluorine-18 and carbon-11 labeled radioligents for positron emission tomography (pet) imaging for lrrk2

摘要

patent summary: "Fluoride-18 and carbon-11 labeled radioligents for positron emission tomography (pet) imaging for lrrk2". The present invention relates to a method for lrrk2 positron emission tomography (pet) imaging in the tissue of an individual, the method comprising: administering a compound of formula (i), formula (ii) or formula (iii) or a pharmaceutically acceptable salt thereof to the individual, wherein the compound includes at least one c11 or f18 label thereon; allow the compound to penetrate the tissue of the subject; and collect a pet image of the individual's cns or brain tissue.