首页> 外国专利> Solid forms of (1R, 4R) - 6 '- Fluoro - N, N - dimethyl - 4 - phenyl - 4', 9 '- dihydro - 3' H - espiro - cyclohexane - 1,1 '- Piran 3,4, b indole - 4 - amine and sulfuric acid.

Solid forms of (1R, 4R) - 6 '- Fluoro - N, N - dimethyl - 4 - phenyl - 4', 9 '- dihydro - 3' H - espiro - cyclohexane - 1,1 '- Piran 3,4, b indole - 4 - amine and sulfuric acid.

机译:(1R,4R)-6'-氟-N,N-二甲基-4-苯基-4',9'-二氢-3'H-螺盐-[环己烷-1,1'-Piran [3, 4,b]吲哚]-4-胺和硫酸。

摘要

Abstract solid forms of (1R, 4R) - 6 '- Fluoro - N, N - dimethyl - 4 - phenyl - 4', 9 '- dihydro - 3' H - espiro - [cyclohexane - 1,1 '- Piran [3,4, b] indole] - 4 - amine and sulfuric acid.The invention relates to solid forms of (1R, 4R) - 6 '- Fluoro - N, N - dimethyl - 4 - phenyl - 4', 9 '- dihydro - 3' H - espiro [cyclohexane - 1,1 '- Piran [3,4b] indole] - 4 - amine and sulfuric acid, such as sulphate or hemissulfato (1R, 4R) - 6' - Fluoro - N, N - dimethyl - 4 - phenyl - 4 ', 9' - dihydro - 3 'H - espiro [ciclohexa In the - 1,1 '- Piran [3,4b] indole] - 4 - amine, in particular, crystalline forms and / or amorphous forms thereof,Pharmaceutical compositions and medicines that include these solid forms, the use of these solid forms, as well as a process for its production.
机译:(1R,4R)-6'-氟-N,N-二甲基-4-苯基-4',9'-二氢-3'H-螺盐-[环己烷-1,1'-Piran [3 ,4,b]吲哚] -4-胺和硫酸。本发明涉及固体形式的(1R,4R)-6′-氟-N,N-二甲基-4-苯基-4′,9′-二氢-3'H-espiro [环己烷-1,1'-Piran [3,4b]吲哚]-4-胺和硫酸,例如硫酸盐或半硫酸盐(1R,4R)-6'-氟-N,N-二甲基-4-苯基-4',9'-二氢-3'H-螺盐[环己基在-1,1'-吡喃[3,4b]吲哚]-4-胺,特别是晶体形式和/或其无定形形式,包括这些固体形式的药物组合物和药物,这些固体形式的用途以及其生产方法。

著录项

  • 公开/公告号BR112014014164A8

    专利类型

  • 公开/公告日2017-06-13

    原文格式PDF

  • 申请/专利权人 GRÜNENTHAL GMBH;

    申请/专利号BR20141114164

  • 发明设计人 MICHAEL GRUSS;STEFAN KLUGE;STEFAN PRÜHS;

    申请日2012-12-11

  • 分类号C07D491/107;A61K31/407;A61P29;

  • 国家 BR

  • 入库时间 2022-08-21 13:40:32

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