pessary cerclage containing long, sustained and sustained release progesterone useful for preventing premature birth

摘要

pessary cerclage containing progesterone containing long, sustained and continuous release useful for preventing premature labor pessary cerclage containing progesterone homogeneously distributed in the body of the pessary providing prolonged, sustained and continuous release over a period of at least 6 months, in which The pessary consists of dimethylsiloxane with rtv (room temperature vulcanization) elastomer mechanism, the amount of progesterone is from 20% to 30% w / w, relative to the weight of pessary and the ratios of the matrix forming polymers is from 6: 1 to 14: 1. Pessary cerclage is useful for preventing premature birth. progesterone diffuses through the polymer continuously, without changing the shape and integrity of the pessary since the elastomer forming the polymeric matrix used herein is not biodegradable. This ensures that the pessary form remains intact until the end of treatment.