hydroxyalkyl methyl cellulose acetate succinate, composition, solid dispersion, process for producing a solid dispersion, dosage form and capsule

摘要

summary "hydroxyalkyl methyl cellulose acetate succinate, composition, solid dispersion, process for producing a solid dispersion, dosage form and shell" new hydroxyalkyl methyl cellulose acetate succinates which a) have from 4.0 to less than 10.0 percent by weight of succinoyl groups, b) have a weight average molecular weight mw of 80,000 daltons to 350,000 daltons, and c) exhibit turbidity of up to 41 ntu as a 1.5 percent by weight solution in acetone; and novel hydroxyalkyl methyl cellulose acetate succinates which a) have from 10.0 to 20.0 weight percent succinyl groups, b) have a weight average molecular weight mw of 80,000 daltons to 350,000 daltons, and c) exhibit a turbidity of up to 41 ntu as a 1.5 weight percent solution in acetone, are useful for preparing solid dispersions of active ingredients in these hydroxyalkyl methyl cellulose acetate succinates.