CONNECTIONS TO THE RECEPTOR OF THE GROWTH FACTOR FACTOR OF 3 TYPE FIBROBLASTES (FGFR3) AND METHODS OF THERAPY

摘要

According to the present invention, conjugates comprising a drug component and a cell binding agent that specifically target the receptor for growth factor fibroblast type 3 (FGFR3) are proposed. These conjugates have therapeutic use, since they are designed and specifically designed to target a specific cell population and to deliver strong cytotoxin into the cell. The conjugate according to the present invention has significant advantages over other conjugates known in the art, providing targeted tumor therapy, as well as the existence of a "witness effect" in relation to neighboring cells, based on an important receptor for oncology, which is only expressed at a moderate level.