INCREASING CELLULAR LIPID PRODUCTION BY INCREASINGTHE ACTIVITY OF DIACYLGLYCEROL ACYLTRANSFERASE AND DECREASING THE ACTIVITY OF TRIACYLGLYCEROL LIPASE

摘要

TGL3 Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up regulating diacylglycerol acyltransferase and down regulating triacylglycerol lipase. In some embodiments a DGA1 protein is expressed and a native gene is knocked out thereby increasing the synthesis of triacylglycerol and decreasing its consumption respectively.