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A NOVEL FORMULATION TO TRANSDERMALLY DELIVER ANTIHYPERTENSIVE AGENT WITH PERMEABILITY ENHANCER
A NOVEL FORMULATION TO TRANSDERMALLY DELIVER ANTIHYPERTENSIVE AGENT WITH PERMEABILITY ENHANCER
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机译:一种新型配方,可透皮输送抗渗透性增强剂
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摘要
This invention relates to a novel formulation to dermally/ transdermally/ transmucosally deliver a pharmaceutically active principle at a therapeutically effective rate by a skin permeation enhancing factor comprising sabinene hydrate 1-5% w/v, a cosolvent ethanol 0-40% v/v in the main solvent isotonic phosphate buffer (pH-7.4) and the method of preparation thereof comprising the steps of, preparing a subsaturated or saturated drug solution in the vehicle, ie ethanol: IPB (pH 7.4) (40:60) mixture, adding sabinene hydrate to donor phase in increasing concentration ie 1%, 3% and 5%.
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