PREPARATION OF HIGHLY EFFICIENT HETEROGENEOUS CATALYST FOR ASYMMETRIC NITROALDOL REACTION

摘要

The present invention relates to the preparation of highly efficient chiral heterogeneous catalyst for asymmetric nitroaldol reaction, wherein Henry reactions of various aldehydes such as aromatic, aliphatic, α,ß-unsaturated aldehydes, alicyclic aldehydes and nitroalkenes were carried out to produce optically active ß-nitroalcohols in high yield, and with moderate to excellent enantioselectivity (ee up to 99 %) in presence of a base and an optically active chiral heterogeneous catalyst.