ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS.

摘要

The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula (I): A-(L-D)p or a pharmaceutically acceptable salts or solvates thereof, wherein A is an antibody that selectively binds FAP; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.