Monoklonale antistoff betegnet X120.545.1.1. og gitt ATCC aksesjonsnummer PTA-5803 eller en humanisert form av nevnte antistoff som binder spesifikt til STEAP-1, en modifisert form derav, et rekombinant protein derav, et deponert hybridom, en vektor som koder for antistoffet eller fragmentet, farmasøytisk preparat derav, samt anvendelser derav, blant annet til fremstilling av et medikament.

摘要

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.