Selective pyridine capacitive isocyclohexane derivatives for the treatment of inflammatory, metabolic, oncological and autoimmune diseases

摘要

It refers to an optional isocyclohexane derivative, which is concentrated from the prepared pyridine (I) or its salts, hydrates, solutions, polymorphs and stereoisomers: y is NR u; R is h or C1-C4 optional alternative tar; R1 is h-oh, among others; R2 is h, halogen, etc.; R3a is C1-C6, alcox C1-C6 optional tar. Among other alternatives, R3b and R3C are h-cn or mixed into an oxo group; R4A is h, halogen, etc.; r4b is h, oxo, etc.; R5 is (cr8r9), etc.; R5 is (cr8r9), etc.; N and P are 0-4 integrity; r6a and R6b are h, halogen, C1-C6 tar, etc.; R8, R9 and R12 are h, C1-C6 are substitutes, etc;B refers to the ring system, such as arilo, heterosexual, etc. It is a selected compound: n6-cycloacrylonitrile-5-fluoro-n4 - [4 - (1h-tetrazol-5-methyl) phenyl] - N6 - [[4 - (trifluoromethyl) phenyl] methyl] pyridine-4, 6-diamond, etc. You also mean a composer These compounds regulate the activity of the hole receptor associated with the retinoic acid receptor (ROR). This compound is useful in the treatment of inflammatory, metabolic and autoimmune diseases.