首页> 外国专利> 3,4-DIHYDROPYRROLO(1,2-A)PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

3,4-DIHYDROPYRROLO(1,2-A)PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

机译:3,4-二氢吡咯(1,2-A)吡嗪-2,8(1H)-二甲酰胺衍生物,其制备和治疗用途

摘要

Compounds corresponding to the general formula (I) wherein R2 represents a group C1-10-alkyl, C3-10-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyl-C3-7-cycloalkyl, C3-7-cycloalkyl-C3-7-cycloalkyl, C1-6-alkylthio-C-1-10-alkyl, C1-6-alkoxy-C1-10-alkyl, hydroxy-C1-10-alkyl, hydroxy-C1-6-alkyl-C3-7-cycloalkyl-C1-6-alkyl, hydroxy-C3-10-cycloalkyl, C1-10-fluoroalkyl or C3-10-fluorocycloalkyl; an optionally substituted heterocyclic group; a group C1-10-alkyl substituted with an optionally substituted heterocyclic group; X6 represents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-fluoroalkyl or cyano; and R7 represents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents, in the form of the base or of an acid-addition salt, and the therapeutic use thereof.
机译:对应于通式(I)的化合物,其中R 2代表基团C 1-10烷基,C 3-10-环烷基,C 3-7-环烷基-C 1-6-烷基,C 1-6-烷基-C 3-7-环烷基, C3-7-环烷基-C3-7-环烷基,C1-6-烷硫基-C-1-10-烷基,C1-6-烷氧基-C1-10-烷基,羟基-C1-10-烷基,羟基-C1- 6-烷基-C3-7-环烷基-C1-6-烷基,羟基-C3-10-环烷基,C1-10-氟代烷基或C3-10-氟代环烷基;任选取代的杂环基;被任选取代的杂环基取代的C 1-10烷基; X6代表选自氢,氟,氯和溴原子的基团,或基团C1-6-烷基,C3-7-环烷基,C3-7-环烷基-C1-6-烷基,C1-6-氟代烷基或氰基; R7代表碱或酸加成盐形式的任选被一个或多个取代基取代的芳基,例如苯基或萘基,及其治疗用途。

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