Telomerase reverse transcriptase as protection against aging

摘要

A nucleic acid vector comprising a telomerase reverse transcriptase (TERT) coding sequence for use in the treatment or prevention of an age-related disorder in an adult without the concomitant use of a cancer suppressor, in the that treatment does not significantly increase the incidence of cancer in the subject, the nucleic acid vector is a non-integrative vector and targets post-mitotic tissues, the adult is a human, and the age-related disorder is selected from the osteoporosis group, glucose intolerance, insulin resistance, memory loss and loss of neuromuscular coordination, or combinations thereof.