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Crush-resistant oxycodone tablets intended to prevent inadvertent misuse and illegal diversion of use

机译:旨在防止误滥用和非法转移使用的抗压羟考酮片

摘要

Water-insoluble matrix tablets based on oxycodone or one of its pharmaceutically acceptable salts, which can release oxycodone in the body for a long time and that comprise oxycodone inside a compression matrix, said matrix being constituted by a mixture of microcrystalline cellulose and by [poly (vinyl acetate) / polyvinylpyrrolidone (80:20)], said compression matrix further comprising an agent that increases the viscosity that allows the formation of a gel when the tablet is dissolved in a minimum water, characterized in that: - oxycodone or a pharmaceutically acceptable salt thereof represents 10 to 50% by weight of the total weight of the tablet, - said compression matrix represents 50 to 98% by weight of the total weight of said tablet. compressed, advantageously from 85 to 95%, - said mixture of microcrystalline cellulose and [polyvinyl acetate / polyvinylpyrrolidone (80:20)] represents 40 to 100%, advantageously from 50 to 90% by weight of the total weight of the die, and - are obtained by applying compression forces between 10 kN and 160 kN.
机译:基于羟考酮或其药学上可接受的盐之一的水不溶性基质片剂,其可在体内长时间释放羟考酮,并在压缩基质内包含羟考酮,所述基质由微晶纤维素和[ (乙酸乙烯酯)/聚乙烯吡咯烷酮(80:20)],所述压缩基质还包含增加粘度的试剂,当将片剂溶解在最低限度的水中时,该粘度允许形成凝胶,其特征在于:-羟考酮或药物其可接受的盐占片剂总重量的10至50重量%;-所述压缩基质占所述片剂总重量的50至98重量%。压缩,有利地为85至95%,-所述微晶纤维素和[聚乙酸乙烯酯/聚乙烯吡咯烷酮(80∶20)的混合物]占模具总重量的40至100%,有利地为50至90%,和-通过施加10 kN至160 kN之间的压缩力获得。

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