Water-insoluble matrix tablets based on oxycodone or one of its pharmaceutically acceptable salts, which can release oxycodone in the body for a long time and that comprise oxycodone inside a compression matrix, said matrix being constituted by a mixture of microcrystalline cellulose and by [poly (vinyl acetate) / polyvinylpyrrolidone (80:20)], said compression matrix further comprising an agent that increases the viscosity that allows the formation of a gel when the tablet is dissolved in a minimum water, characterized in that: - oxycodone or a pharmaceutically acceptable salt thereof represents 10 to 50% by weight of the total weight of the tablet, - said compression matrix represents 50 to 98% by weight of the total weight of said tablet. compressed, advantageously from 85 to 95%, - said mixture of microcrystalline cellulose and [polyvinyl acetate / polyvinylpyrrolidone (80:20)] represents 40 to 100%, advantageously from 50 to 90% by weight of the total weight of the die, and - are obtained by applying compression forces between 10 kN and 160 kN.
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