Pyridone derivatives and derivatives thereof in the treatment of tuberculosis

摘要

A compound of Formula (I) ** Formula ** in which R1 is H, methyl or ethyl; R2 is phenyl, pyrrole or pyrazole, wherein said phenyl is optionally substituted with one or more substituents independently selected from fluoro or chloro; with the proviso that when said substituent is chlorine, said chlorine is in the meta or ota position of said phenyl and the number of chlorine substituents is not more than one; R3 is a structural formula selected from the group consisting of ** Formula ** where R100 and R200 are each independently selected from the group consisting of H, (C1-C6) alkyl, cycloalkyl, an organic cation and an inorganic cation; R4 is H or -C ( = O) NH2; R5 is selected from the group consisting of (C1-C6) alkyl, cycloalkyl, phenyl, heterocycle and heteroaryl, optionally substituted with one or more independent R300 substituents; and R300 is selected from the group consisting of H, (C1-C6) alkyl, cycloalkyl, hydroxy, amino and F; or a pharmaceutically acceptable salt thereof.