Derivatives of 3,4,4a, 10b-tetrahydro-1h-thiopyran- 4,3-c isoquinoline

摘要

Fixed combination comprising 3- [1 - ({4 - [(4aR, 10bR) -9-ethoxy-8-methoxy-3,4,4a, 10b-tetrahydro-1H-thiopyran [4,3- c] isoquinolin- 6-yl] phenyl} carbonyl) piperidin-4-yl] -1 - [(2-ethyl-2H-tetrazol-5-yl) methyl] -6-phenylthiene [3,2-d] pyrimidine-2,4 ( 1H, 3H) - dione (hereinafter referred to as "Compound A"), at least one therapeutic agent selected from the group consisting of corticosteroids, anticholinergics, adrenoceptor-β2 agonists, H1 receptor antagonists, receptor antagonists leukotriene, 5-lipoxygenase inhibitors, endothelin receptor antagonists, prostacyclines, calcium channel blockers, beta blockers, phosphodiesterase type 4 inhibitors, phosphodiesterase type 5 inhibitors, immunosuppressants, vitamin D analogs, HMG-CoA inhibitors -reductase, pulmonary surfactants, antibiotics, guanilyl cyclase activators / stimulators, tetrahydrobiopterin and tetrahydrobiopterin derivatives, anticoagulants, diuretics, pirfenidone and gli digital cosides, and at least one pharmaceutically acceptable auxiliary.