Synthesis procedure of 3,4-dimethoxybicyclo 4.2.0 octa-1,3,5-triene-7-carbonitrile and its application to the synthesis of ivabradine and its addition salts of a pharmaceutically acceptable acid

摘要

Synthesis procedure of the compound of formula (I): ** Formula ** characterized in that the compound of formula (VII) ** Formula ** is subjected to the action of 1- (isocyanomethylsulfonyl) -4-methylbenzene (TosMIC) in the presence of a base, in an organic solvent, to lead to the compound of formula (I).