首页> 外国专利> Succinic acid salt of the 1- 2- (2-chloro-4 - {(R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethylaminomethyl ester } - 5-Methoxyphenylcarbamoyl) ethyl biphenyl-2-ylcarbamic acid piperidin-4-yl and its use for the treatment of pulmonary disorders

Succinic acid salt of the 1- 2- (2-chloro-4 - {(R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethylaminomethyl ester } - 5-Methoxyphenylcarbamoyl) ethyl biphenyl-2-ylcarbamic acid piperidin-4-yl and its use for the treatment of pulmonary disorders

机译:1- [2-(2-氯-4-{[(R)-2-羟基-2-(8-羟基-2-氧代-1,2-二氢喹啉-5-基)]乙基氨基甲基酯的琥珀酸盐]}-5-甲氧基苯基氨基甲酰基)乙基]联苯基-2-基氨基甲酸哌啶丁-4-基及其在治疗肺部疾病中的用途

摘要

An ester succinic acid salt 1- [2- (2-chloro-4 - {[(R) -2-hydroxy-2- (8-hydroxy-2-oxo-1,2-dihydroquinolin-5- yl)) ethylamino] methyl} -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl of biphenyl-2-ylcarbamic acid, which is the crystalline solid form Form 1 characterized by an X-ray powder diffraction pattern that has diffraction peaks at 2θ values of 5.0, 5.7, 7.1, 10.0, 12.6, 13.8, 14.4, 15.5, 16.1, 16.4, 16.9, 17 , 8, 18.5, 20.2, 20.5, 21.4, 25.3, 25.8 and 26.3.
机译:琥珀酸酯盐1- [2-(2-氯-4--{[(R)-2-羟基-2-(8-羟基-2-氧代-1,2-二氢喹啉-5-基))乙氨基联苯-2-基氨基甲酸的[]甲基} -5-甲氧基苯基氨基甲酰基)乙基]哌啶-4-基,为晶型1的固体结晶,其特征在于X射线粉末衍射图谱的衍射峰在2θ值为5.0时, 5.7、7.1、10.0、12.6、13.8、14.4、15.5、16.1、16.4、16.9、17、8、18.5、20.2、20.5、21.4、25.3、25.8和26.3。

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