ANTAGONISTIC CD28 MONOVALENT DOMAIN ANTIBODIES

摘要

Disclosed are domain antibodies that monovalently bind CD28. Domain antibodiesthat are monovalent forbind-ing of CD28 can inhibit CD28 activity. In one aspect, a domain antibodyconsists of or comprises a single immunoglobulinvari-able domain that specifically binds and antagonizes the activity of CD28,in an aspect, without substantially agonizing CD28ac-tivity. In another aspect, the domain antibody is a human domain antibody.The disclosure further encompasses methods ofantag-onizing CD80 and/or CD86 interactions with CD28 in an individual andmethods of treating diseases or disorders involving CD80and/or CD86 interactions with CD28, the methods involving administering adomain antibody to the individual.