TARGETED-DELIVERY OF SMALL INTERFERENCE RNA AGAINST ANTHRAX

摘要

The present invention includes a composition for the targeted-delivery of small interference RNA against bacteria comprising: a detoxified bacterial protein toxin that comprises a highly positively charged region; and an siRNA that is specific to, and knocks-down expression of one or more genes related to one or more virulence factors of the bacteria, wherein the siRNA is bound to the highly positively charged region of the detoxified bacterial protein toxin.