Process for the Synthesis of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Compounds, and Application in the Synthesis of Ivabradine

摘要

#$%^&*AU2014201355B220170824.pdf#####Process for the Synthesis of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Compounds, and Application in the Synthesis of Ivabradine Abstract A process for the synthesis of the compound of formula (I): H3CO NR (I) H3CO 0 wherein R represents apara-methoxybenzyl (PMB) group or the following group: OCH3 I2 N OCH3 H3C is disclosed. Also disclosed is the application of the compound of formula (I) in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.