Method of discovery of effective components in herbals based on evidences by reversed-directed analysis

摘要

Conventional methods in this field include identifying and screening compounds in a laboratory setting with cells and animals, and then moving on to clinical trials with a promising compound. To complicate the issue with these methods, effective compounds might not exist in the original herbals, multiple compounds might be involved with outcomes, long study period and high cost. The method described above might bypass bottlenecks such as, 1) promising compounds are identified from test patients who demonstrate preferred and safe results; 2) more than one compound might be identified; 3) safe and effective compounds might be metabolites and not exist in herbals. The process includes a website to collect clinical information. The promising compounds can be determined by analyzing common components from patients. Information for potential compounds are directly obtained from human being, application of the invention will tremendously reduce the time and costs involved in research and development of new drugs.