BACTERIAL PROTEASES TARGETING THE NF-KB TRANSCRIPTION FACTOR FAMILY

摘要

The present invention provides compositions and methods for treating or preventing a disease or disorder associated with increased NF-κΒ signaling. In certain aspects, the invention may be used treating cancer or inflammatory diseases. In one aspect, the invention is an agent which cleaves the NF-κΒ transcription factors RelA, RelB, cRel or a combination thereof. In another aspect, PipA, GtgA or GogA proteins or nucleic acids which encode PipA, GtgA or GogA inhibit NF-κΒ signaling.