Process for the Preparation of Ziconotide

摘要

The present invention is a solid phase (solid phase) through the synthesis in place of the conventional ultrasound method for synthesizing a peptide (sonication) and heating treatment, the solid phase synthesis proceeds in a nitrogen gas stream conditions (SPPS method) and a liquid or solid phase synthesis (solution- phase) mixture of synthetic (convergence method), a method of producing a novel not suited Kono (Ziconotide). According to the invention, is the improved separation and purification of lactide Kono after its synthesis are available commercially mass-produced. In addition, the present invention is to improve the yield and purity than the method not suited Kono synthesized by the art to be used in the technical field there are economic benefits in terms of production cost. ;