A METHOD FOR THE PRODUCTION OF BIOADHESIVE COMPACT MATRICES

摘要

Preparing a homogeneous mixture of an alkyl cellulose or hydroxyalkyl cellulose and a powder comprising a water-insoluble, water-swellable crosslinked polymer; Preparing a compression unit starting from such a powder mixture by direct compression, and heating the compression unit thus obtained at a temperature in the range of 80 to 250 占 폚 for 1-60 minutes, The powder mixture further comprises at least one active substance, wherein the resulting compression unit is characterized by slow release and the release rate of the active substance in aqueous solution at pH 4-8 is substantially zero.