22--1- 22- Process for preparing 22-difluoroethylamine derivatives by alkylation with 22-difluoro-1-haloethanes

摘要

A 2,2-difluoroethyl-1-haloethane compound of formula (I) is reacted with an amine of formula (II) optionally in the presence of a base to give the 2,2-difluoroethylamine derivative of formula (III) How to make: Wherein A is an optionally substituted heterocycle as described in the specification, Hal is Cl, Br or I.