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USE OF TETRA-SUBSTITUTED DERIVATIVES 4,3-D PYRIMIDINE FOR TREATMENT OF DIABETIC NEPHROPATHY
USE OF TETRA-SUBSTITUTED DERIVATIVES 4,3-D PYRIMIDINE FOR TREATMENT OF DIABETIC NEPHROPATHY
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机译:四取代衍生物[4,3-D]嘧啶在治疗糖尿病性肾病中的应用
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1.1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d ] pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, for use in the treatment of end-stage chronic renal failure. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one carrier, diluent or excipient for use in the treatment of end-stage chronic renal failure. 3. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, for use in the treatment of diabetic nephropathy. 4. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one carrier, diluent or excipient for use in the treatment of diabetic nephropathy. 5. 1- (2-Ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide or a pharmaceutically acceptable salt thereof, for use in the treatment of chronic kidney disease. 6. The use of claim 5, wherein the chronic kidney disease is stage 3 or 4.7. 1- (2-ethoxyethyl) -5- (ethyl (methyl) amino) -7 - ((4-methylpyridin-2-yl) amino) -N- (methylsulfonyl) -1H-pyrazolo [4,3-d] pyrimidine -3-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one carrier, diluent or excipient for use in the treatment of chronic kidney disease. The use of claim 7, wherein the chronic kidney disease is stage 3 or 4.9.
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