The described invention provides an ex vivo model of persistent T lymphocyte stimulation events encountered by circulating T lymphocytes at lymph node and tissue levels in vivo; a method for optimizing donor selection for allogeneic blood and marrow transplantation (BMT) therapy; and a method for minimizing risks and maximizing benefits of performing allogeneic blood and marrow transplantation (BMT) therapy in a recipient subject, wherein the recipient subject has a hematologic malignancy.
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