METHOD FOR ASYMMETRICALLY CATALYZED SYNTHESIS OF NITROPYRAZOLE AMIDE COMPOUND

摘要

A paroxetine intermediate, a method for preparing the same, and uses thereof are provided. Specifically, the method includes: reacting a compound of formula I below with a compound of formula II in the presence of an organic base under the catalysis of a complex formed from a chiral amine oxide L and a rare-earth metal compound Ln(OTf) 3 to prepare a compound of formula III below: wherein R 1 is alkyl, phenyl or benzyl; R 2 , R 3 , R 4 are each independently C 1 -C 6 alkyl or C 6 -C 10 aryl; the chiral amine oxide L has the following structure: wherein n = 1,2; and R = Ph-, 2,6-Me 2 C 6 H 3 -, 2,6-Et 2 C 6 H 3 -, 2,6-iPr 2 C 6 H 3 -, Ph 2 CH-.