DERIVATIVES OF THE DISODIUM 2,2'-{CARBONYLBISIMINO-3,1-PHENYLENECARBONYLIMINO(1-METHYL-1H-PYRROLE-4,2-DIYL)CARBONYLIMINO}DINAPHTHALENE-1,5-DISULFONATE SALT AND RELATED COMPOUNDS AS HEPARANASE INHIBITORS FOR THE TREATMENT OF CANCER

摘要

The present invention relates to ureido derivatives of naphtalenesulfonic acids having an anti-heparanase activity.In particular, it relates to compounds of formula (I)for use in the treatment of diseases where an inhibition of heparanase is desired, in particular cancer.The present invention also relates in particular to derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds.