N-PYRROLIDINYL, N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

摘要

PROBLEM TO BE SOLVED: To provide TrkA inhibitors that can be used in treatment of, e.g., pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, Sjogren's syndrome, endometriosis, or pelvic pain syndrome.SOLUTION: The invention provides compounds of formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof. (In the formula, Ring B and the NH-C(=X)-NH moiety are in the trans configuration; and R, R, Rand Rare independently selected from H and (1-3C) alkyl, where Rand Rtogether with the atom to which they are attached may form a cyclopropyl ring.)SELECTED DRAWING: None