Process for the preparation of crystalline forms of posaconazole intermediate and amorphous posaconazole

摘要

The present invention provides an industrial process for the production of amorphous posaconazole. The invention also relates to a process for the production of posaconazole via a posaconazole intermediate and a novel crystalline form of said posaconazole intermediate. More specifically, the present invention relates to a novel crystalline form of a posaconazole intermediate represented by Structural Formula III below and a method for the production of a novel crystalline form of a posaconazole intermediate, said intermediate comprising the production of posaconazole Is an important intermediate. The present invention also provides a one-pot process for the preparation of amorphous posaconazole using a novel crystalline form of benzyl posaconazole. [Selection] Figure 3-1