USE OF HER2 DIMERIZATION INHIBITOR PERTUZUMAB AND PRODUCTS CONTAINING PERTUZUMAB

摘要

PROBLEM TO BE SOLVED: To provide therapeutic agents for HER2-positive breast cancer and the like.SOLUTION: The invention provides use of Pertuzumab being an inhibitor of HER2 dimerization and products comprising it. In particular, the application describes methods for extending progression-free survival period in a population of HER2-positive breast cancer patients; combining two HER2 antibodies to treat HER2-positive cancer without increasing cardiac toxicity; treating early-stage HER2-positive breast cancer; treating HER2-positive cancer by co-administering a mixture of Pertuzumab and Trastuzumab from the same intravenous drip bag; treating HER2-positive metastatic gastric cancer; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and Vinorelbine; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and an aromatase inhibitor; and treating low HER3 ovarian, primary peritoneal, or fallopian tube cancer.SELECTED DRAWING: None