HEPATITIS TISSUE BODY, INFECTION METHOD OF HEPATITIS VIRUS, MANUFACTURING METHOD OF HEPATITIS TISSUE BODY, PROLIFERATION METHOD OF HEPATITIS VIRUS, MANUFACTURING METHOD OF HEPATITIS VACCINE, SCREENING METHOD, AND KIT

摘要

PROBLEM TO BE SOLVED: To provide a hepatitis tissue body which has a tissue structure similar to a hepatic lobule being a constituent unit of a liver, is capable of being infected with a hepatitis virus, and efficiently proliferating a hepatitis virus.SOLUTION: 1) A hepatitis tissue body which imitates a hepatic tissue infected with a hepatitis virus contains an endothelial cell having a tubular structure, and a cell mass formed on the endothelial cell having the tubular structure, in which at least a part of a cell constituting the cell mass holds a hepatitis virus. 2) The hepatitis tissue body in which the cell mass formed on the endothelial cell having the tubular structure contains at least one cell type selected from the group consisting a hepatocyte, hepatocyte progenitor cell, a cell derived from a hepatoblast liver and hepatocyte lineage cell.