首页> 外国专利> MONOVALENT, BIVALENT AND TRIVALENT ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) NANOBODY CONSTRUCTS FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS

MONOVALENT, BIVALENT AND TRIVALENT ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) NANOBODY CONSTRUCTS FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS

机译:用于预防和/或治疗呼吸道感染的新颖,重要和重要的人类呼吸道合胞病毒(HRSV)纳米抗体构建体

摘要

Amino acid sequences are provided that are directed against/and or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV.;The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.
机译:提供了针对/和/或可以特异性结合hRSV的蛋白F的氨基酸序列,以及包含或基本上由一种或多种此类氨基酸序列组成的化合物或构建体,尤其是蛋白质和多肽。本发明提供的氨基酸序列,多肽以及治疗性化合物和组合物显示出对hRSV的蛋白F的改善的稳定性,较低的免疫原性和/或改善的亲和力和/或亲和力。本发明还涉及此类氨基酸序列的用途。用于预防和/或治疗目的的多肽,化合物或构建体。

著录项

  • 公开/公告号US2018105581A1

    专利类型

  • 公开/公告日2018-04-19

    原文格式PDF

  • 申请/专利权人 ABLYNX N.V.;

    申请/专利号US201715712247

  • 申请日2017-09-22

  • 分类号C07K16/10;A61M11;A61M15;A61K39;

  • 国家 US

  • 入库时间 2022-08-21 13:05:13

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